The aim of this study was to produce gliclazide loaded eudragit® L100-55 microparticles by coacervation technique in order to achieve pH responsive drug release using hydroxypropyl methycellulose (HPMC) as stabilizer and Poloxamer 407 as surfactant. The effect of enteric polymer: HPMC ratio on properties of microparticles was investigated with regard to particle size distribution, morphology, yield, encapsulation efficiency, in-vitro drug release profiles and interaction between gliclazide and eudragit® L100-55. Average % drug entrapment efficiency was seen in all microparticles. Particle diameter increased when the enteric polymer content was higher relative to HPMC. In-vitro dissolution studies demonstrated that the drug release from the microparticles was dependent upon enteric polymer: HPMC ratio and particle size distribution. At the ratio of at least 3:1 of enteric polymer: HPMC, drug release was suppressed most significantly in low pH (hydrochloric acid as medium) while rapid drug release was observed in pH 7.4.
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